![]() Also, there was a "dramatic reduction of lines and wrinkles" after applying 0.2% HPR around the eyes twice a day for 14 days. According to the manufacturer's tests, 24 hours of an occlusive patch with 0.5% HPR resulted in significantly lower irritation than 0.5% retinol. The big promise of HPR is that it's similarly active as retinoic acid (no conversion needed, remember) but without the irritation. It binds directly to the retinoid receptors of the skin cells to work its skincare magic. Other forms of retinoids have to be converted by our metabolic machinery to do something. If you've already read our description about retinol or retinyl palmitate, you know that the active ingredient our skin cells can interpret is retinoic acid. It's a so-called retinoic acid ester, meaning that it's directly related to retinoic acid. When a product claims 2% Granactive Retinoid, it means 0.2% Hydroxypinacolone Retinoate (and 1.8% dimethyl isosorbide) on the ingredient list. The manufacturer produces it as 10% active and 90% solvent called dimethyl isosorbide. Good to know: the trade name of HPR is Granactive Retinoid. The queen of the family is the FDA-approved anti-aging superstar, retinoic acid, aka tretinoin and HPR seems to be a gentle but influential sister princess to the queen. Hydroxypinacolone Retinoate (HPR) is the newest member of the "royal family of skincare" ( see who is who on this cool retinoids family tree), the retinoid family.
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